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33 ; Shechter, M. et al. Effects of oral magnesium therapy on exercise tolerance, exercise- induced chest pain, and quality of life in patients with coronary artery disease. American Journal of Cardiology, 2003; 91 5 517-521 Abstract: -Previous studies have demonstrated that magnesium supplementation improves endothelial function in patients with coronary artery disease CAD ; . However, the impact on clinical outcomes, such as exercise-induced chest pain, exercise tolerance, and quality of life, has not been established. In a multicenter, multinational, prospective, randomized, double-blind and placebocontrolled trial, 187 patients with CAD 151 men, 36 women; mean SD age 63 10 years, range 42 to 83 ; were randomized to receive either oral magnesium 15 mmol twice daily Magnosolv-Granulat, total magnesium 365 mg provided as magnesium citrate ; n 94 ; or placebo n 93 ; for 6 months. Symptom-limited exercise testing Bruce protocol ; and responses given on quality-of-life questionnaires were the outcomes measured. Magnesium therapy significantly increased intracellular magnesium levels Mg ; i ; in substudy of 106 patients at 6 months compared with placebo 35.5 3.7 vs 32.6 2.9 mEq L, p 0.0151 ; . Magnesium treatment significantly increased exercise duration time compared with placebo 8.7 2.1 vs 7.8 2.9 minutes, p 0.0075 ; , and lessened exerciseinduced chest pain 8% vs 21%, p 0.0237 ; . Quality-of-life parameters significantly improved in the magnesium group. These findings suggest that oral magnesium supplementation in patients with CAD for 6 months results in a significant improvement in exercise tolerance, exercise-induced chest pain, and quality of life, suggesting a potential mechanism whereby magnesium could beneficially alter outcomes in patients with CAD.
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