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T 03 PANCREATIC CYSTIC LESIONS : DIFFERENT PROGNOSES. V. Casneuf, L. Delrue, P. Demetter, M. De Vos, B. de Hemptinne, M. Peeters. Ghent University Hospital. Objectives : A retrospective analysis of disease free and overall survival of patients with benign and malign cystic lesions of the pancreas. Methods : Identification of patients with a cystic lesion of the pancreas, referred to our hospital during the last ten years, by searching throughregistration systems of our hospital and medical files. Final diagnoses were based on pathologic data or long term clinical follow-up. Referring physicians were contacted for actual survival data when necessary. Results : Forty-two patients were identified and could be followed up until death or until survival on October 2004. There were 20 adenocarcinomas with cystic components, 6 serous cystadenomas, 7 mucinous cystadenomas, 6 cystadenocarcinomas and 3 intraductal papillary mucinous tumours IPMN ; . Seventeen of 20 adenocarcinomas underwent a R0 resection. This group has a mean disease free survival DFS ; of 20.6 months range 2-92 ; and a mean overall survival OS ; of 27.7months range 5-92 ; . Three patients underwent a R1 resection for an adenocarcinoma, and had a mean OS of 9.3 months range 6-14 ; . Four of 6 serous cystadenomas underwent a R0 resection of which 1 died immediately postoperative and is excluded from the analysis ; , 1 underwent enucleation, and 1 did not undergo surgery, because of old age diagnosis is based on radiology and clinical follow-up ; . This group has a mean DFS and OS of 61.6 range 28-150 months ; . All 7 mucinous cystadenomas underwent a R0 resection, with amean DFSof 71.0 months range 15144 months ; anda mean OSof 81.4 months range 53-144 months ; . All 6 cystadenocarcinomas underwent R0 resection, though 1 died immediately postoperative and was excluded from the analysis.Mean DFS in this group is 33.0 months range 5-66 months ; andmean OS is 39.2 months range 12-66 months ; . Three patients with IPMN underwent a R0 resection. They have a mean DFS and OS of 15.3 months range 2-40 months ; . When comparing DFS and OS between groups, the following significant differences were demonstrated : patients with mucinous cystadenomas had a significantly longer DFS in comparison to cystadenocarcinoma t 2.25, P 0.05 ; and adenocarcinoma t 3.8, P 0.01 ; .OS for mucinous cystadenomaswas also significant different from cystadenocarcinoma t 2.83, P 0.05 ; and from adenocarcinoma t 4.78, P 0.001 ; . Conclusions : This study demonstrates that patients with mucinous cystadenomas present a clinical subgroup, with a clear better prognosis than carcinomas. No differences were found between adenocarcinomas with cystic degenerationand cystadenocarcinomas. No differences were found between mucinous and serous cystadenomas.

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Exhibit 13 CERTIFICATION OF THE CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of Teva Pharmaceutical Industries Limited the "Company" ; on Form 20-F for the period ended December 31, 2005 as filed with the Securities and Exchange Commission on the date hereof the "Report" ; , we, Israel Makov, Chief Executive Officer of the Company, and Dan S. Suesskind, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. 1350, as adopted pursuant to 906 of the Sarbanes-Oxley Act of 2002, that: 1 ; 2 ; The Report fully complies with the requirements of section 13 a ; or the Securities Exchange Act of 1934; and The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
This work is published in the 15 october issue of genes and development bilodeau et al, genes dev 2006, 71-2886 ; and it was supported by grants from the national cancer institute of canada and from the canadian institutes of health research and tenormin.
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