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QFD has been applied in a wide range of subjects; not only for developing products and services but also for defining organizational structures e.g. see Jacobs & Dygert, 1997; and Hales, 1998 ; . QFD can also be used in strategic planning, although there are differences when applying it to developing manufacturing strategy and resolving manufacturing strategic issues. Table 1 highlights these differences. Further discussion regarding table 1 can be found in Crowe & Cheng 1996 ; . However, it is worth mentioning that the authors argue that in the product design process, customers' requirements and preferences are somewhat more static in nature, whereas in competitive business environment, the competitive priorities are more dynamic. In some cases such an affirmation is not entirely true, i.e. there are industrial sectors where the product design process must be very dynamic such as in the computing and software industries. Figure 1 illustrates the three phases of strategic planning through the use of QFD, as suggested by Crowe & Cheng 1996 ; . These phases are: functional strategies, manufacturing priorities, action plans, and detailed tasks and starlix.

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Submitted 18 January 2001. From the Department of Family and Community Medicine JGS ; , Wake Forest University School of Medicine, Winston-Salem, NC. Address reprint requests to John G. Spangler, MD, MPH, Department of Family and Community Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1084.

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In human medicine, the phrase `continuous muscle fibre activity' CMFA ; has been applied to a heterogeneous group of hereditary and acquired conditions that share the feature of sustained involuntary muscle contractions of peripheral nerve origin, conditions which must be differentiated from central disorders and primary muscle disorders Auger and others 1984, Auger 1991, 1994 ; . In conditions of peripheral nerve origin, the CMFA is due to the hyperactivity of peripheral nerve motor axons. These conditions do not stem from a single disease process but are the result of the response of peripheral nerves to several different insults, each of which affects nerve function and induces the spontaneous activity of motor axons. As a result, they vary in their clinical signs, associated electrophysiological abnormalities and morphological findings. However, they share the feature of sustained involuntary muscle contraction Auger 1991, 1994, Odabasi and others. 991 A central role for nuclear factor of activated T cells NFAT ; in human pulmonary arterial hypertension Sebastien Bonnet, Stephen Archer, Alois Haromy, Evangelos Michelakis. Pulmonary Hypertension Program, Department of Medicine Cardiology ; , University of Alberta, Edmonton, AB, Canada Pulmonary Arterial Hypertension PAH ; is characterized by apoptosis-resistant, proliferative and inflammatory vascular remodeling; it is also associated with selective down-regulation of Kv1.5, a K + channel that regulates the membrane potential of pulmonary artery smooth muscle cells PASMC ; . This results in depolarization, causing a ; increased influx of [Ca + ]i from voltage-gated Ca + channels and enhanced proliferation and b ; increase in [K]i which suppresses apoptosis by tonically inhibiting caspases. The mechanism of Kv1.5 down-regulation is unknown. We hypothesized that Kv1.5 is regulated by NFAT, a calcineurinsensitive transcription factor. We studied PASMC normoxic or hypoxic ; , lungs and blood from 11 PAH and 12 healthy patients. Compared to normal, hypoxic and PAH PASMC had 60%-decreased Kv current, decreased Kv1.5 expression and 40%-increased [Ca + ]i. Hypoxic and PAH PASMC and lungs showed activation of NFAT1 nuclear translocation ; compared to normals. Inhibition of NFAT1 by VIVIT a competing peptide ; or cyclosporine, "normalized" the hypoxic and PAH PASMC, increasing Kv1.5 and Kv current and decreasing [Ca + ]i; resulting in decreased proliferation and increased apoptosis in vitro. In vivo, cyclosporine treatment for 3 weeks reversed monocrotaline-PAH in rats n 10 ; , improving hemodynamics, right ventricular and PA medial hypertrophy. NFAT1 levels were increased in peripheral blood cells in PAH compared to healthy patients and CD3-positive lymphocytes with activated NFAT1 were seen in the vessel wall in PAH but not normal lungs. NFAT1 might regulate the anti-apoptotic, proliferative and inflammatory vascular remodeling and be a novel therapeutic target in PAH, for example, sporanox injection. Award recipients Dr. Athena Philis-Tsimikas, Chief Medical Director of the Whittier Institute for Diabetes and Project Dulce, and Chris Walker, Executive Director, Project Dulce. Bob Lawrence was born in Plymouth in 1941. He left school at 14 to work in the grocery trade. After serving in the RAF, he continued his education then went to Bristol University. In 1967 he suffered a serious road accident. He gained a medical degree in 1974. He is married with three children and lives in Swansea. His medical career included General Medicine and Surgery, Accident and Emergency, Anaesthetics, Intensive Care and General Practice. From 1982-1986 he was employed by the Ministry of Defence as Ship's Surgeon with the Royal Fleet Auxiliary. He saw service in the Falklands and other parts of the world. hen I was first diagnosed with MS, I had been aware of symptoms for a number of years. At that time there was no available treatment for MS except steroids and, knowing the penalties of such drugs, I was reluctant to consider these as an appropriate long-term therapy. The obvious alternative was to research all the information then currently available. From this, I soon discovered a wide range of mainly dietary factors, which appeared to be relevant to treatment. Gradually, I started making changes to my diet and adding an increasing range of supplements, which I considered of potential benefit. Slowly I started feeling better until at the present time I seem to remain generally well and, as far as the MS is concerned, stable with no relapses and a minimal rate of disease progression. Technology was still new and unpredictable. Since the 1985 and 1986 applications provide no disclosure of either how to make and use chimeric antibodies or working examples of chimeric antibodies within the scope of the ' 561 patent' claims, the applications were not s enabled for chimeric antibodies. Conclusion: Because substantial evidence supported the jury' verdict that the ' patent s 561 cannot claim priority to any of the 1984, 1985 and 1986 applications, the CAFC affirmed the judgment of the district court. 5. ADDITION OF " " DESCRIPTIVE TERM DOES NOT TYPICALLY MAKE PROPOSED MARK REGISTRABLE In re Oppedahl & Larson LLP, 373 F.3d 1171, 71 U.S.P.Q.2d BNA ; 1370 Fed. Cir. June 25, 2004 ; Issue: Is there an absolute prohibition on the use of a top-level domain indicator, such as " ", to make an otherwise descriptive or generic mark registrable? Answer: No. Facts: In 2001, appellant Oppedahl & Larson LLP filed an intent-to-use application to register the mark "patents " and identified the relevant goods as "[c]omputer software for managing a database of records and for tracking the status of the records by means of the Internet." The USPTO refused to register the mark based on a finding that the mark was merely descriptive of the applicant' goods. s Specifically, the USPTO found that the term "patents" describes a feature of the goods, and the term " " is top-level domain indicator TLD ; without any trademark significance. The Trademark Trial and Appeal Board "the Board" ; affirmed the USPTO' decision citing s prior cases in which it held that " " has no source-identifying significance and that the addition of a TLD to an otherwise descriptive or generic term did not make the proposed mark registrable. Oppedahl & Larson appealed. s Argument: Appellant challenges the Board' application of a strict rule that allegedly always disregards the use of " " and other TLDs in a trademark application. According to the appellant, the USPTO erred by cutting off the TLDs before evaluating the consumer' s. I Table 1. Demographic Characteristics of the Study Sample.
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